目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs810488Ki-16425 355025-24-0
| 參考價 | ￥909-￥9041 |
參考價：￥909 ~ ￥9041
5mg 10mg 50mg >
CAS:355025-24-0 純度:＞98% 分子量:474.96 分子式:C23H23ClN2O5S 供貨周期:現(xiàn)貨 規(guī)格:5mg 貨號:abs810488 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a competitive, potent and reversible
>| 5mg | 909元 | 999mg可售 |
| 10mg | 1359元 | 999mg可售 |
| 50mg | 5336元 | 999mg可售 |
更新時間：2026-02-05 09:33:05瀏覽次數(shù)：1144評價
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| CAS | 355025-24-0 | 純度 | ＞98% |
|---|---|---|---|
| 分子量 | 474.96 | 分子式 | C23H23ClN2O5S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5mg |
| 貨號 | abs810488 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a competitive, potent and reversible |
Ki-16425 355025-24-0
| 產(chǎn)品描述 | |
| 描述 | Ki-16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | Debio 0719；Ki16425 |
| 外觀 | white powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (210.54 mM) |
| 生物活性 | |
| 靶點 | LPL Receptor |
| In vitro(體外研究) | Ki-16425 (10 μM; 1.5 hours; HEK293A cells) treatment blocks LPA-induced dephosphorylation of YAP/TAZ in HEK293A cells. Ki16425 partially inhibits the ability of serum to repress YAP/TAZ phosphorylation, particularly at low serum concentrations (0.2%). |
| In vivo(體內(nèi)研究) | Ki-16425 (Debio 0719) (1-30 mg/kg; i.p.; at 30 min prior to LPA injection) inhibits LPA-induced neuropathic pain-like behaviors. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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