目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs810514TAE-226 761437-28-9
| 參考價 | ￥1225-￥9030 |
參考價：￥1225 ~ ￥9030
5mg 10mg 50mg >
CAS:761437-28-9 純度:＞98% 分子量:468.94 分子式:C23H25ClN6O3 供貨周期:現(xiàn)貨 規(guī)格:5mg 貨號:abs810514 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a potent FAK inhibitor with IC50 of 5
>| 5mg | 1225元 | 999mg可售 |
| 10mg | 1960元 | 999mg可售 |
| 50mg | 6321元 | 999mg可售 |
更新時間：2026-02-05 13:17:37瀏覽次數(shù)：1288評價
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| CAS | 761437-28-9 | 純度 | ＞98% |
|---|---|---|---|
| 分子量 | 468.94 | 分子式 | C23H25ClN6O3 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5mg |
| 貨號 | abs810514 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a potent FAK inhibitor with IC50 of 5 |
TAE-226 761437-28-9
| 產(chǎn)品描述 | |
| 描述 | TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | TAE226, TAE-226,TAE 226,NVPTAE226 |
| 外觀 | Powder |
| 可溶性/溶解性 | DMSO 94 mg/mL (200.45 mM) |
| 生物活性 | |
| 靶點 | PYK2 ,FAK ,Insulin Receptor ,IGF-1R ,c-Met |
| In vitro(體外研究) | NVP-TAE226 ( NVP-TAE226 (5 μM) inhibits phosphorylation of FAK in the human neuroblastoma cell line SK-N-AS. NVP-TAE226 ( NVP-TAE226 (0.1 μM-10 μM) inhibits tube formation of HMEC1 cells. |
| In vivo(體內(nèi)研究) | NVP-TAE226 (75 mg/kg) significantly increases the survival rate of mice bearing intracranial glioma xenografts. NVP-TAE226 (100 mg/kg, oral) exerts significant decrease in microvessel density in a human colon cancer model in SCID mice. NVP-TAE226 (100 mg/kg, oral) efficiently inhibits MIA PaCa-2 human pancreatic tumor growth without body weight loss in vivo model. NVP-TAE226 inhibits 4T1 murine breast tumor growth and metastasis to the lung in a dose-dependent manner in vivo model, associated with inhibition of FAK autophosphorylation at Y397 and Akt phosphorylation at Serine473. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer MetabolismResponse to hypoxia MetabolismPathways and ProcessesMetabolism processesHypoxia Signal TransductionProtein PhosphorylationTyrosine KinasesFAK / PYK Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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